Adina Stanculescu, PhD

Assistant Professor of Biology


Faculty Since 2019

Education

BA, University of Illinois at Chicago
PhD, University of Illinois at Chicago

Contact

[email protected]

Dr. Stanculescu has a background in biopharmaceutical sciences. Her pre- and post-doctoral research focused on understanding cellular mechanisms of resistance to cancer therapy. Pathways explored included those involved in apoptosis, inflammation, and endocrine hormone signaling. The culmination of that work identified potential biomarkers as early predictors of tumor response to therapy. Her results have been published in a variety of journals and shared at national conferences. She has also researched the medicinal properties of botanicals traditionally used in the treatment of gastrointestinal disorders (published as A. Stoia). Dr. Stanculescu enjoys traveling with her family and reading scientific and biblical literature.

Selected Publications

Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, Stanculescu A, Bocchetta M, Rizzo P, Band V, Band H,  Kim HM, Park SK, Kang KW, Avantaggiati ML, Gomez CR, Golde T, Osborne B, Miele L. p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex Via MAML1. J Cell Physiol. 2015;  230:3115-27.  

Bergamaschi A, Frasor J, Borgen K, Stanculescu A, Johnson P, Rowland K, Wiley EL, Katzenellenbogen BS. 14-3-3ζ as a  predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers.  Breast Cancer Res Treat. 2013; 137:689-96.  

Stanculescu A, Bembinster LA, Borgen K, Bergamaschi A, Wiley E, Frasor J. Estrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner. Horm Cancer. 2010; 1:127-35.

Frasor J, Weaver A, Pradhan M, Dai Y, Miller LD, Lin CY, Stanculescu A. Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer. Cancer Res. 2009; 69:8918-25.  

Afshar Y, Stanculescu A, Miele L, Fazleabas AT. The role of chorionic gonadotropin and Notch1 in implantation. J Assist  Reprod Genet. 2007; 24:296-302.  

Zhao Y, Katzman RB, Delmolino L, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng  MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V. The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem. 2007; 282:11969-81.  

Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005;  19:988-91.  

Mahady GB, Pendland SL, Yun GS, Lu ZZ, Stoia A. Ginger (Zingiber officinale Roscoe), and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. Anticancer Res. 2003; 23:3699-702.  

Mahady GB, Pendland SL, Stoia A, Chadwick LR. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis Canadensis. Phytother Res. 2003; 17:217-21.

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